a 江西师范大学化学化工学院 南昌 330022;
b 南昌大学第一附属医院检验科 南昌 330026;
c 江西省人民医院外科 南昌 330006
“One-Pot” Synthesis of 5-(1-Phenyl-3-phenylprop-2-ynyl)-2,2-dimethyl-1,3-dioxane-4,6-dione Catalyzed by Copper Acetate
Xu Zhaohuia, Chen Feibiaoa, Li Yuyua, Huang Qingshuib, Liao Chuanwenc
a Chemistry and Chemical Engineering Department, Jiangxi Normal University, Nanchang 330022;
b Clinical Laboratory, First Affiliated Hospital of Nanchang University, Nanchang 330026;
c Department of General Surgery, Jiangxi Province People's Hospital, Nanchang 330006
In the presence of copper acetate, ten 5-(1-phenyl-3-phenylprop-2-ynyl)-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives were synthesized via the three component one-pot reaction of aldehydes with 2,2-dimethyl-1,3-dioxane-4,6-dione and phenylacetylene by using Na-ascorbate as a reductant. The reaction has the advantages of high yields (65%~86%), mild conditions, simple operation and environmental friendliness. It provides an effective method for the synthesis of 5-(1-phenyl-3-phenylprop-2-ynyl)-2,2-dimethyl-1,3-dioxane-4,6-dione derivatives.
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2018, Vol. 38 
